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chemistry tool kit  (OpenEye Scientific Software Inc)

 
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    OpenEye Scientific Software Inc chemistry tool kit
    Chemistry Tool Kit, supplied by OpenEye Scientific Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/chemistry+tool+kit/chemistry+toolkit/pmc04215758-113-12-11
    Average 90 stars, based on 1 article reviews
    chemistry tool kit - by Bioz Stars, 2026-11
    90/100 stars

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    Related Articles

    other:

    Article Title: The ‘SAR Matrix’ method and its extensions for applications in medicinal chemistry and chemogenomics
    Article Snippet: Java programs were written, in part with the aid of the OpenEye chemistry tool kit , to identify A_MMS and generate, rank, and display SARMs.

    Article Title: The ‘SAR Matrix’ method and its extensions for applications in medicinal chemistry and chemogenomics
    Article Snippet: We describe the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) methodology that is based upon a special two-step application of the matched molecular pair (MMP) formalism.. The SARM method has originally been designed for the extraction, organization, and visualization of compound series and associated SAR information from compound data sets.. It has been further developed and adapted for other applications including compound design, activity prediction, library extension, and the navigation of multi-target activity spaces.



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    H 2 O 2 inhibits global protein synthesis. Cells were treated for 80 min with H 2 O 2 and MnTMPyP as indicated prior to addition of <t>OPP</t> or vehicle. Cells were incubated for an additional 40 min prior to harvest and global protein synthesis analysis. ( A ) Newly synthesized protein signal is AZdye <t>647</t> fluorescence. Total protein assessed by Coomassie staining. Images are representative of two biological replicates with two technical replicates each. ( B ) Quantitation of pixel intensity for all replicates, normalized to total protein per lane. * p < 0.001 for H 2 O 2 versus H 2 O 2 + MnTMPyP. No asterisk indicates p > 0.05.
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    Image Search Results


    H 2 O 2 inhibits global protein synthesis. Cells were treated for 80 min with H 2 O 2 and MnTMPyP as indicated prior to addition of OPP or vehicle. Cells were incubated for an additional 40 min prior to harvest and global protein synthesis analysis. ( A ) Newly synthesized protein signal is AZdye 647 fluorescence. Total protein assessed by Coomassie staining. Images are representative of two biological replicates with two technical replicates each. ( B ) Quantitation of pixel intensity for all replicates, normalized to total protein per lane. * p < 0.001 for H 2 O 2 versus H 2 O 2 + MnTMPyP. No asterisk indicates p > 0.05.

    Journal: Antioxidants

    Article Title: Acute Oxidative Stress Can Paradoxically Suppress Human NRF2 Protein Synthesis by Inhibiting Global Protein Translation

    doi: 10.3390/antiox12091735

    Figure Lengend Snippet: H 2 O 2 inhibits global protein synthesis. Cells were treated for 80 min with H 2 O 2 and MnTMPyP as indicated prior to addition of OPP or vehicle. Cells were incubated for an additional 40 min prior to harvest and global protein synthesis analysis. ( A ) Newly synthesized protein signal is AZdye 647 fluorescence. Total protein assessed by Coomassie staining. Images are representative of two biological replicates with two technical replicates each. ( B ) Quantitation of pixel intensity for all replicates, normalized to total protein per lane. * p < 0.001 for H 2 O 2 versus H 2 O 2 + MnTMPyP. No asterisk indicates p > 0.05.

    Article Snippet: The reagents in the Click-&-Go Plus 647 OPP Protein Synthesis Assay Kit (Click Chemistry Tools, #1496, Scottsdale, AZ, USA) were stored at 4 °C, except the AZDye 647 Azide Plus, which was dissolved in DMSO and stored in the dark at −20 °C per manufacturer instructions.

    Techniques: Incubation, Synthesized, Fluorescence, Staining, Quantitation Assay